Characterization and demonstration of drug compound ring-chain tautomer formation and its impacts on quality control
Jenny Ottosson, Malin Gränfors, Sally van Pelt, Annika Langborg Weinmann, Sten O. Nilsson Lill, Gustaf Hulthe, Gunnar Grönberg
Topics & Concepts
TautomerChemistryImpurityCharacterization (materials science)Ring (chemistry)Computational chemistryMass spectrometryNuclear magnetic resonance spectroscopyDensity functional theorySpectroscopyAnalytical Chemistry (journal)ChromatographyStereochemistryOrganic chemistryNanotechnologyPhysicsMaterials scienceQuantum mechanicsChemical synthesis and pharmacological studiesAnalytical Methods in PharmaceuticalsChemical Thermodynamics and Molecular Structure