Doxorubicin induces dysregulation of AMPA receptor and impairs hippocampal synaptic plasticity leading to learning and memory deficits
Ahmad Alhowail, Priyanka D. Pinky, Matthew Eggert, Jenna Bloemer, Lauren N. Woodie, Manal Buabeid, Subhrajit Bhattacharya, Shanese L. Jasper, Dwipayan Bhattacharya, Muralikrishnan Dhanasekaran, Martha Escobar, Robert D. Arnold, Vishnu Suppiramaniam
Abstract
+/calmodulin-dependent protein kinase (CaMKII), and brain-derived neurotrophic factor (BDNF) were observed. This was also accompanied by an increase in extracellular signal regulated kinase (ERK) and protein kinase B (AKT) activation. Together these data suggest that Dox-induced cognitive impairments are at least partially due to alterations in the expression and functionality of the glutamatergic AMPAR system.
Topics & Concepts
AMPA receptorNeuroscienceSynaptic plasticityHippocampal formationSynaptic scalingHomeostatic plasticityPsychologyMetaplasticityMedicineReceptorGlutamate receptorInternal medicineCancer-related cognitive impairment studiesNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms