Discovery of Novel Iminosugar Compounds Produced by <i>Lactobacillus paragasseri</i> MJM60645 and Their Anti-Biofilm Activity against Streptococcus mutans
Mingkun Gu, Jinhua Cheng, Yeong‐Geun Lee, Joo-Hyung Cho, Joo‐Won Suh
Abstract
In this study, we isolated lactic acid bacteria that inhibit streptococcal biofilm from the oral cavity of infants and identified two novel compounds from the supernatant of their culture broth. The two compounds are structurally similar, and both consist of iminosugars, glycerol, and unsaturated fatty acid. A search of the SciFinder database revealed that these structures are novel and were discovered for the first time in this study. Mechanism studies have shown that these compounds can inhibit the expression of biofilm synthesis-related genes. This is the first report that lactic acid bacteria inhibit streptococcal biofilms by small molecules with new chemical structures. This study not only expands the understanding of natural products derived from lactic acid bacteria but also provides a new paradigm for the understanding of the interaction of bacteria in the oral microbiota.