The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms
Mahmudul Hasan, Hamed Khakzad, Lotta Happonen, Anders Sundin, Johan Unge, U. Müeller, Johan Malmström, Gunilla Westergren‐Thorsson, Lars Malmström, Ulf Ellervik, Anders Malmström, Emil Tykesson
Abstract
-glycosylation of the protein. Additionally, the structure of DS-epi1 reveals a high structural similarity to proteins from several families of bacterial polysaccharide lyases. DS-epi1 is of great importance in a range of diseases, and the structure provides a necessary starting point for design of active site inhibitors.
Topics & Concepts
Dermatan sulfateEpimerGlucuronic acidChemistrySulfateStereochemistryBiochemistryOrganic chemistryPolysaccharideHeparan sulfateGlycosaminoglycanGlycosylation and Glycoproteins ResearchProteoglycans and glycosaminoglycans researchProtein Structure and Dynamics