Strengthening the link between mitophagy and Parkinson’s disease
Ian G. Ganley
Abstract
This scientific commentary refers to ‘Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci’ by Soutar et al. (https://doi.org/10.1093/brain/awac325); and ‘DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy’ by Imberechts et al. (https://doi.org/10.1093/brain/awac313).
Topics & Concepts
MitophagyParkinPINK1MediatorNeuroscienceParkinson's diseaseDiseaseBiologyGeneticsMedicineAutophagyBioinformaticsPsychologyCell biologyInternal medicineApoptosisAutophagy in Disease and TherapyParkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling