MnO<sub>2</sub>-based nanoparticles remodeling tumor micro-environment to augment sonodynamic immunotherapy against breast cancer
Haiqin Liao, Mingyu Chen, Zhipeng Liao, Yi Luo, Sijie Chen, Long Wang, Zhi Gang Wang, Chengcheng Niu
Abstract
into cytotoxic hydroxyl radicals (˙OH). This study thus lays the foundation for advancing cancer nanomedicine, offering a novel approach that integrates TME remodelling with sonodynamic immunotherapy.
Topics & Concepts
Tumor microenvironmentHydrogen peroxideSonodynamic therapyChemistryGlutathioneBreast cancerCancer researchImmunotherapyTumor-associated macrophageHuman breastBreast tumorCancerCancer immunotherapyBiochemistryReactive oxygen speciesTumor cellsMedicineInternal medicineEnzymeNanoplatforms for cancer theranosticsPhotoacoustic and Ultrasonic ImagingUltrasound and Hyperthermia Applications