De novo variants in CUL3 are associated with global developmental delays with or without infantile spasms
Mitsuko Nakashima, Mitsuhiro Kato, Masaru Matsukura, Ryutaro Kira, Lock Hock Ngu, Klaske D. Lichtenbelt, Koen L.I. van Gassen, Satomi Mitsuhashi, Hirotomo Saitsu, Naomichi Matsumoto
Topics & Concepts
CullinUbiquitinBiologyProteasomeUbiquitin ligaseFrameshift mutationCell biologyGeneticsMutationGeneUbiquitin and proteasome pathwaysGenetics and Neurodevelopmental DisordersAutophagy in Disease and Therapy