Change in the Gut Microbiome and Immunity by Lacticaseibacillusrhamnosus Probio-M9
Meng Zhang, Yan Zheng, Zheng Sun, Chenxia Cao, Wei Zhao, Yangshuo Liu, Wenyi Zhang, Heping Zhang
Abstract
Although the global market for probiotics is growing explosively, there is still an active debate about whether the consumption of probiotics is beneficial for nonpatients. In this study, we recruited 100 adults from a college in China and performed 6 weeks of intervention for half of the volunteers. By analyzing the time series multiomics data in this study, we found that the probiotic intervention (i) has a limited effect on human immunity or the global structure of the gut microbiome and metabolome, (ii) can largely influence the correlation of the development between multiomics data and immunity, which was not able to be discovered by conventional differential abundance analysis, and (iii) can inhibit the generation of SNVs in the gut microbiome instead of promoting it.