Exopolysaccharides produced by <i>Lactobacillus rhamnosus</i> GG alleviate hydrogen peroxide-induced intestinal oxidative damage and apoptosis through the Keap1/Nrf2 and Bax/Bcl-2 pathways <i>in vitro</i>
Jinze Li, Qiuke Li, Nan Gao, Zhihua Wang, Feng Li, Jianping Li, Anshan Shan
Abstract
-damaged IPEC-J2 cells and had no cytotoxic activity, suggesting that EPSs produced by LGG may be an effective drug for relieving oxidative stress. Our study provided a theoretical basis for exploration of the application of probiotic secondary metabolites in practice.
Topics & Concepts
Lactobacillus rhamnosusOxidative stressKEAP1ApoptosisChemistrySuperoxideHydrogen peroxideFerrousDPPHProbioticAntioxidantBiochemistryLactobacillusBiologyBacteriaTranscription factorOrganic chemistryFermentationGeneGeneticsEnzymeGut microbiota and healthMedicinal Plants and Bioactive CompoundsNeuroinflammation and Neurodegeneration Mechanisms