Impact of Latent Tuberculosis on Diabetes
Burcu Tepekule, Katharina Kusejko, Marius Zeeb, Philip Tarr, Alexandra Calmy, Manuel Battegay, Hansjakob Furrer, Matthias Cavassini, Enos Bernasconi, Julia Notter, Huldrych F. Günthard, Johannes Nemeth, Roger D. Kouyos, Swiss HIV Cohort Study, Irène A. Abela, Karoline Aebi‐Popp, A Anagnostopoulos, M Battegay, Enos Bernasconi, Dominique L. Braun, Heiner C. Bucher, Alexandra Calmy, Matthias Cavassini, Angela Ciuffi, G Dollenmaier, Matthias Egger, Luigia Elzi, Jan Fehr, Jacques Fellay, Hansjakob Furrer, C A Fux, Huldrych F. Günthard, Anna Hachfeld, David Haerry, Barbara Hasse, Hans H. Hirsch, Matthias Hoffmann, Irène Hösli, M Huber, Christian R. Kahlert, Laurent Kaiser, Olivia Keiser, Thomas Klimkait, Roger D. Kouyos, Helen Kovari, Katharina Kusejko, G Martinetti, Begoña Martínez de Tejada, Catia Marzolini, Karin J. Metzner, N Müller, Johannes Nemeth, Dunja Nicca, P Paioni, Giuseppe Pantaleo, Matthieu Perreau, Andri Rauch, Patrick Schmid, Roberto F. Speck, M Stöckle, Philip Tarr, Alexandra Trkola, Gilles Wandeler, Sabine Yerly
Abstract
While an increased risk of active and latent tuberculosis infection (LTBI) in people with type-2 diabetes (DM) has been demonstrated, it is less well characterized whether LTBI is associated with an increased risk of developing DM. We investigated the link between LTBI and DM in people living with HIV in the Swiss HIV Cohort Study via time-dependent Cox proportional hazards models. We found that LTBI significantly increased the risk of developing DM (HR = 1.47), which was robust across different adjustment and censoring techniques. Our results thus suggest that LTBI may be associated with an increased risk of developing DM.