Design, synthesis and anticancer evaluation of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 1,8-naphthyridine-3-carboxamide moiety as novel multi-target TKIs
Pengqin Chen, Ying Zhao, Jianqing Zhang, Yongli Duan, Jintian Dai, Jie He, Xiemin Wang, Xi Chen, Pan Chen, Weixin Zhao, Xu Wang, Zaishou Zhuang, Daona Yang, Guang Liang, Qidong Tang
Topics & Concepts
HeLaChemistryMoietyIC50Docking (animal)Receptor tyrosine kinaseCarboxamideStereochemistryLead compoundKinaseTyrosine kinaseA549 cellApoptosisPharmacologyCombinatorial chemistryReceptorIn vitroBiochemistryBiologyNursingMedicineLiver physiology and pathologyPI3K/AKT/mTOR signaling in cancerCancer Mechanisms and Therapy