Molecular complementarity and structural heterogeneity within co-assembled peptide β-sheet nanofibers
Kong M. Wong, Yiming Wang, Dillon T. Seroski, Grant E. Larkin, Anil Mehta, Gregory A. Hudalla, Carol K. Hall, Anant K. Paravastu
Abstract
pattern, dipolar recoupling measurements on isotopically diluted nanofiber samples reveal a non-negligible amount of self-associated (AA and BB) pairs. Furthermore, computational simulations predict these different structures can coexist within the same nanofiber. Our results highlight structural disorder at the molecular level in a charge-complementary peptide system with implications on co-assembling peptide designs.
Topics & Concepts
NanofiberComplementarity (molecular biology)Beta sheetPeptideNanotechnologyMaterials scienceSelf-assemblyChemistryBiochemistryBiologyGeneticsSupramolecular Self-Assembly in MaterialsChemical Synthesis and AnalysisPolydiacetylene-based materials and applications