Legionella pneumophila Excludes Autophagy Adaptors from the Ubiquitin-Labeled Vacuole in Which It Resides
Titilayo O. Omotade, Craig R. Roy
Abstract
Xenophagy targets intracellular pathogens for destruction by the host autophagy pathway. Ubiquitin chains are conjugated to xenophagic targets and recruit multiple autophagy adaptors. The intracellular pathogen Legionella pneumophila resides in a vacuole that is ubiquitinated; however, this pathogen avoids xenophagic detection. Here, the mechanisms by which L. pneumophila can prevent the host xenophagy pathway from targeting the vacuole in which it resides were examined.
Topics & Concepts
VacuoleLegionella pneumophilaAutophagyBiologyLegionellaUbiquitinMicrobiologyCell biologyAmoeba (genus)VirologyBacteriaBiochemistryCytoplasmGeneticsApoptosisGeneLegionella and Acanthamoeba researchAutophagy in Disease and Therapy