Cisplatin and oleanolic acid Co-loaded pH-sensitive CaCO<sub>3</sub>nanoparticles for synergistic chemotherapy
Muhammad Waseem Khan, Chenming Zou, Said Hassan, Fakhar ud Din, Mahaman Yacoubou Abdoul Razak, Asif Nawaz, Alam Zeb, Abdul Wahab, Sudhair Abbas Bangash
Abstract
imaging study revealed that DiR-loaded NPs were concentrated more in tumors for a longer period of time as compared to other peritoneal tissues in tumor bearing mice, demonstrating the site specificity of the delivery system. On the other hand, hematoxylin and eosin (H&E) staining of Kunming mice kidney tissue sections revealed that OA greatly reduced CDDP induced nephrotoxicity in the formulation. Overall, these results confirmed that our pH-sensitive dual loaded drug delivery system offers a handy direction for effective and safer combination chemotherapy.
Topics & Concepts
CisplatinOleanolic acidChemistryNanoparticleChemotherapyPharmacologyNuclear chemistryNanotechnologyMedicineMaterials scienceInternal medicinePathologyAlternative medicineNanoparticle-Based Drug DeliveryBone Tissue Engineering MaterialsEnzyme function and inhibition