SYTL4 downregulates microtubule stability and confers paclitaxel resistance in triple-negative breast cancer
Xiyu Liu, Wang Jiang, Ding Ma, Li‐Ping Ge, Yun‐Song Yang, Zongchao Gou, Xiao‐En Xu, Zhi‐Ming Shao, Yi‐Zhou Jiang
Abstract
SYTL4 is a novel chemoresistant gene in TNBC and its upregulation indicates poor prognosis in taxane-treated TNBC. Further, SYTL4 directly binds microtubules and decreases microtubule stability.
Topics & Concepts
Triple-negative breast cancerTaxaneCancer researchPaclitaxelMicrotubuleRNA interferenceBiologyBreast cancerCancerCell biologyGeneRNAGeneticsMicrotubule and mitosis dynamicsBioinformatics and Genomic Networks14-3-3 protein interactions