A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model
Shirin Strohmeier, Fatima Amanat, Xueyong Zhu, Meagan McMahon, Meagan E. Deming, Marcela F. Pasetti, Kathleen M. Neuzil, Ian A. Wilson, Florian Krammer
Abstract
Influenza virus infections remain a high risk to human health, causing up to 650,000 deaths worldwide every year, with an enormous burden on the health care system. Since currently available seasonal vaccines are only partially effective and often mismatched to the circulating strains, a broader protective influenza virus vaccine is needed. Here, we generated a recombinant influenza virus vaccine candidate based on the more conserved neuraminidase surface glycoprotein in order to induce a robust and broader protective immune response against a variety of circulating influenza virus strains.
Topics & Concepts
NeuraminidaseVirologyMeasles virusVirusAntigenic driftBiologyHemagglutinin (influenza)Influenza A virusH5N1 genetic structureMicrobiologyRecombinant DNAPotexvirusEpitopeRecombinant virusOrthomyxoviridaeVaccinationInfluenza vaccineMeasles vaccineImmune systemParamyxoviridaeAntigenic shiftEmbryonatedPhosphoproteinNeurotropic virusSemliki Forest virusViral matrix proteinSendai virusMononegaviralesInfluenza A virus subtype H5N1Original antigenic sinAntigenInfluenza Virus Research StudiesVirology and Viral DiseasesRespiratory viral infections research