Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity
Naoko Nakano, Nobuo Sakata, Y. Katsu, Daiki Nochise, Erika Sato, Yuta Takahashi, Saori Yamaguchi, Yoko HAGA, Souichi Ikeno, Mitsuyoshi Motizuki, Keigo Sano, Kohei Yamasaki, Keiji Miyazawa, Susumu Itoh
Abstract
gene in at least two different ways. Of note, TGF-β abrogated DNA damage in B[a]P-exposed cells. We therefore conclude that TGF-β may protect cells against carcinogenesis because it inhibits CYP1A1-mediated metabolic activation of PAHs as part of its anti-tumorigenic activities.
Topics & Concepts
Aryl hydrocarbon receptor nuclear translocatorAryl hydrocarbon receptorChemistryTranscription factorSMADGene silencingGene expressionSignal transductionCell biologyMolecular biologyFOSBRegulation of gene expressionBiologyCancer researchGeneBiochemistryCancer, Hypoxia, and MetabolismEpigenetics and DNA MethylationMetabolism, Diabetes, and Cancer