Clinical and immune responses to anti-CD3 x anti-EGFR bispecific antibody armed activated T cells (EGFR BATs) in pancreatic cancer patients
Lawrence G. Lum, Archana Thakur, Minsig Choi, Abhinav Deol, Vidya Kondadasula, Dana L. Schalk, Kristie Fields, Melissa Dufrense, Philip Philip, Gregory Dyson, Hussein D. Aon, Anthony F. Shields
Abstract
: Infusions of BATs are safe, induce endogenous adaptive anti-tumor responses, and may have a potential to improve overall survival.
Topics & Concepts
Immune systemCancerMedicineBispecific antibodyAntibodyPancreatic cancerCancer researchAntigenCD3ImmunologyInternal medicineMonoclonal antibodyCD8CAR-T cell therapy researchCancer Immunotherapy and BiomarkersPancreatic and Hepatic Oncology Research