Streptococcus pneumoniae Binds to Host Lactate Dehydrogenase via PspA and PspC To Enhance Virulence
Sang‐Sang Park, Norberto González-Juarbe, Eriel Martínez, Joanetha Y. Hale, Yi‐Han Lin, Joshua T. Huffines, Katherine L. Kruckow, David E. Briles, Carlos J. Orihuela
Abstract
co-opts host enzymes for its benefit. They advance our understanding of pneumococcal pathogenesis and have key implications on the susceptibility of individuals with preexisting airway damage that results in LDH-A release.
Topics & Concepts
Streptococcus pneumoniaeVirulenceMicrobiologyVirulence factorPneumoniaLactate dehydrogenaseBiologyGeneMedicineEnzymeGeneticsBiochemistryAntibioticsInternal medicinePneumonia and Respiratory InfectionsStreptococcal Infections and TreatmentsBacterial Infections and Vaccines