Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism
Shawn B. Egri, Christna Ouch, Hui‐Ting Chou, Zhiheng Yu, Kangkang Song, Xu Chen, Kuang Shen
Topics & Concepts
GTPaseBiologyCell biologyRegulatormTORC1Amino acidBinding siteGTPase-activating proteinBiochemistryBiophysicsPhosphorylationSignal transductionGeneG proteinProtein kinase BCRISPR and Genetic EngineeringCellular transport and secretionRNA and protein synthesis mechanisms