Mutations Affecting Mammalian Aging: GH and GHR vs IGF-1 and Insulin
Andrzej Bartke, Holly M. Brown‐Borg
Abstract
A report of extended longevity in mice homozygous for a mutation producing growth hormone (GH) deficiency Since GH is the key determinant of hepatic IGF-1 expression and circulating IGF-1 levels, and has major impact on insulin signaling (Figure Subsequent work provided much evidence in support of this exciting realization
Topics & Concepts
Growth hormone receptorInsulinBiologyInsulin-like growth factorInternal medicineEndocrinologyGeneticsGrowth hormoneCancer researchCell biologyMedicineGrowth factorReceptorHormoneAdipose Tissue and MetabolismMuscle Physiology and DisordersGrowth Hormone and Insulin-like Growth Factors