Development of a selective COX-2 inhibitor: from synthesis to enhanced efficacy <i>via</i> nano-formulation
Marwa Elewa, Mohamed Shehda, Pierre A. Hanna, Mohamed M. Said, Sherif Ramadan, Assem Barakat, Yasmine M. Abdel Aziz
Abstract
This study designs novel 2-benzamido- N -(4-substituted phenyl)thiophene-3-carboxamide derivatives as selective COX-2 inhibitors. Compound VIIa showed strong in vitro anti-inflammatory activity, and incorporating it into niosomes improved its release profile for future in vivo use.
Topics & Concepts
Nano-ChemistryNanotechnologyCombinatorial chemistryMaterials scienceChemical engineeringEngineeringInflammatory mediators and NSAID effectsSynthesis and Biological EvaluationComputational Drug Discovery Methods