Visible-Light-Induced C–H Bond Aminoalkylation of Heterocycles by the Decarboxylation Coupling of Amino Acids
Yifan Li, Changhui Dai, Shentong Xie, Ping Liu, Peipei Sun
Abstract
An efficient visible-light-induced decarboxylative coupling reaction of N-protecting α-amino acids with heterocycles for the generation of aminoalkylated heterocycles is presented. A series of aminoalkylated heterocycles were obtained in moderate to good yields. Attractive features of this process include the generation of aminomethyl radical by an inexpensive organic photocatalyst under transition-metal-free conditions.
Topics & Concepts
ChemistryDecarboxylationCoupling (piping)Amino acidVisible spectrumCombinatorial chemistryCoupling reactionPhotochemistryOrganic chemistryCatalysisOptoelectronicsEngineeringPhysicsMechanical engineeringBiochemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques