NudC regulated Lis1 stability is essential for the maintenance of dynamic microtubule ends in axon terminals
Dane Kawano, Katherine Pinter, Madison Chlebowski, Ronald S. Petralia, Yaxian Wang, Alex Nechiporuk, Catherine M. Drerup
Abstract
axon terminals causes dynein/dynactin accumulation and increased microtubule stability. Microtubule dynamics can be restored by pharmacologically inhibiting dynein, implicating excess dynein motor function in microtubule stabilization. Together, our data support a model in which local NudC-Lis1 modulation of the dynein motor is critical for the regulation of microtubule stability in the axon terminal.
Topics & Concepts
AxonMicrotubuleDyneinCell biologyDynactinAxon terminalBiologyMotor proteinChemistryMicrotubule and mitosis dynamicsPhotosynthetic Processes and MechanismsGlycosylation and Glycoproteins Research