Selenium-incorporated mesoporous silica nanoparticles for osteosarcoma therapy
Lei He, Pamela Habibović, Sabine van Rijt
Abstract
doped in the silica matrix (Se-MSNs) and Se nanoparticles (SeNP) coated with mesoporous silica (SeNP-MSNs), were successfully synthesized. All synthesized nanoparticles were stable in neutral conditions but showed rapid Se release in the presence of glutathione (GSH) and nicotinamide adenine dinucleotide phosphate (NADPH). Furthermore, all nanoparticles were cytotoxic towards SaoS-2 cells and showed significantly lower toxicity towards healthy osteoblasts, where Se doped MSNs showed lowest toxicity towards osteoblasts. We further show that the nanoparticles could induce ROS and cell apoptosis. Here we demonstrate MSNs as promising Se delivery carriers for osteosarcoma (OS) therapy.
Topics & Concepts
Mesoporous silicaSeleniumOsteosarcomaNanoparticleChemistryMesoporous materialNanotechnologyCancer researchMaterials scienceMedicineBiochemistryOrganic chemistryCatalysisSelenium in Biological SystemsCarbon and Quantum Dots ApplicationsCurcumin's Biomedical Applications