RAF kinase dimerization: implications for drug discovery and clinical outcomes
Tilman Brummer, Campbell McInnes
Topics & Concepts
BiologyVemurafenibKinaseSignal transductionDabrafenibCancer researchTyrosine kinaseDrug discoveryMAPK/ERK pathwayAllosteric regulationGTPaseCell biologyBiochemistryMelanomaReceptorMetastatic melanomaMelanoma and MAPK PathwaysComputational Drug Discovery MethodsProtein Kinase Regulation and GTPase Signaling