Duodenal mucosal resurfacing with a GLP-1 receptor agonist increases postprandial unconjugated bile acids in patients with insulin-dependent type 2 diabetes
Suzanne Meiring, Emma C. E. Meessen, Annieke C.G. van Baar, F. Holleman, Max Nieuwdorp, Steven W.M. Olde Damink, Frank G. Schaap, Frédéric M. Vaz, Albert K. Groen, Maarten R. Soeters, Jacques Bergman
Abstract
Glycemic and metabolic improvements are seen in patients with type 2 diabetes after replacing their insulin therapy with DMR and GLP-1. These changes are accompanied by changes in postprandial bile acid concentrations: increased unconjugated and secondary bile acids.
Topics & Concepts
PostprandialFGF19Internal medicineBile acidEndocrinologyFarnesoid X receptorG protein-coupled bile acid receptorInsulinMedicineType 2 diabetesInsulin resistanceGlycemicChemistryDiabetes mellitusReceptorBiochemistryGeneFibroblast growth factorNuclear receptorTranscription factorDiabetes Treatment and ManagementBariatric Surgery and OutcomesGastroesophageal reflux and treatments