Congenital Neuroblastoma
Elena Minakova, Jordan Lang
Abstract
Neuroblastoma is the most common extracranial solid tumor diagnosed during childhood and gives rise to various heterogeneous tumors along the sympathoadrenal axis. Congenital neuroblastoma accounts for 5% of total neuroblastoma cases diagnosed annually, with the majority of cases diagnosed in the first month after birth. Interestingly, neonates demonstrate a unique disease trajectory compared with children older than 1 year of age. This article will provide information on the pathogenesis and variable clinical presentation of congenital neuroblastoma, along with the biological prognostic factors that predict long-term outcomes in affected neonates.
Topics & Concepts
NeuroblastomaMedicinePediatricsPresentation (obstetrics)Solid tumorDiseasePathogenesisInternal medicineSurgeryCancerCell cultureGeneticsBiologyNeuroblastoma Research and TreatmentsIon channel regulation and function