Controlling Surface-Induced Platelet Activation by Agarose and Gelatin-Based Hydrogel Films
Gurunath Apte, Annerose Lindenbauer, Jörg Schemberg, Holger Rothe, Thi‐Huong Nguyen
Abstract
) nanoparticles. While all of the films prevented platelet spreading, films formed by agarose and its nanocomposite repelled platelets and inhibited platelet adhesion and activation stronger than those of gelatin. Our results showed that platelet-surface activation is modulated by controlling the properties of the films underneath platelets and that the bioinert agarose can be potentially translated to the development of platelet storage and other medical applications.
Topics & Concepts
AgaroseGelatinSelf-healing hydrogelsPlatelet activationAdhesionWettingMaterials sciencePlateletPlatelet adhesivenessChemical engineeringSurface modificationNanotechnologyBiomedical engineeringBiophysicsChemistryComposite materialPolymer chemistryChromatographyBiochemistryImmunologyPlatelet aggregationMedicineBiologyEngineeringPolymer Surface Interaction StudiesPeriodontal Regeneration and TreatmentsAdvanced Drug Delivery Systems