B2 cells contribute to hypertension and natural killer cell activation possibly via AT1-AA in response to placental ischemia
Owen Herrock, Evangeline Deer, Lorena M. Amaral, Nathan Campbell, James Lemon, Nicole Ingram, Denise C. Cornelius, Ty W. Turner, Sarah Fitzgerald, Tarek Ibrahim, Ralf Dechend, Gerd Wallukat, Babbette LaMarca
Abstract
This study demonstrates that placental ischemia-stimulated B2 cells induce hypertension and circulating natural killer cell activation and angiotensin II type 1 receptor production in normal pregnant rats.
Topics & Concepts
Angiotensin II receptor type 1PreeclampsiaInternal medicineAngiotensin IIEndocrinologyLosartanMedicineChemistryImmunologyReceptorBiologyPregnancyGeneticsPregnancy and preeclampsia studiesReproductive System and PregnancyBirth, Development, and Health