Endothelial Endothelin Receptor A Expression Is Associated With Podocyte Injury and Oxidative Stress in Patients With Focal Segmental Glomerulosclerosis
Nina A. van de Lest, Aimée E. Bakker, Kyra L. Dijkstra, Malu Zandbergen, Sharon A.C. Heemskerk, Ron Wolterbeek, Jan A. Bruijn, Marion Scharpfenecker
Abstract
INTRODUCTION: R) expression in patients with FSGS and its association with podocyte injury and glomerular oxidative stress. METHODS: R-positive endothelium and with nephrin loss were scored, and the 8-oxo-guanine-positive glomerular area was measured. RESULTS: = 0.037). Finally, 8-oxo-guanine positivity in glomeruli was associated with increased levels of proteinuria. CONCLUSION: R is increased in glomerular endothelial cells of patients with FSGS and associated with podocyte damage and glomerular oxidative stress. These findings support the hypothesis that ET-1 signaling in glomerular endothelial cells contributes to disease development in patients with FSGS.