Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities
Huajian Zhu, Wenlong Li, Shuai Wen, Yang Liu, Limei Yang, Yuchen Tan, Tiandong Zheng, Hong Yao, Jinyi Xu, Zheying Zhu, Dong‐Hua Yang, Zhe‐Sheng Chen, Shengtao Xu
Topics & Concepts
ChemistryTubulinDruggabilityColchicinePharmacologyPaclitaxelToxicityIC50MicrotubuleStereochemistryCancer cellCancerBiochemistryIn vitroOrganic chemistryBiologyGeneMedicineInternal medicineCell biologySynthesis and biological activityMetal complexes synthesis and propertiesClick Chemistry and Applications