Staphylococcus aureus Peptide Methionine Sulfoxide Reductases Protect from Human Whole-Blood Killing
William N. Beavers, Ashley Dumont, Andrew J. Monteith, K. Nichole Maloney, Keri A. Tallman, Andy Weiss, Alec H. Christian, F. Dean Toste, Christopher J. Chang, Ned A. Porter, Victor J. Torres, Eric P. Skaar
Abstract
Oxidative stress is a host defense strategy to control bacterial infections, and bacteria have evolved systems to counteract this innate immune defense. Here, we investigate the peptide methionine sulfoxide reductase system in Staphylococcus aureus that repairs oxidized methionine residues in proteins, preventing the need to resynthesize damaged proteins de novo .
Topics & Concepts
Methionine sulfoxide reductaseStaphylococcus aureusBiologyMethionineMethionine sulfoxideMicrobiologyBacteriaSulfoxideInnate immune systemBiochemistryMSRAPeptideStaphylococcusOxidative stressImmune systemAmino acidImmunologyChemistryGeneticsOrganic chemistryAntimicrobial Peptides and ActivitiesAntimicrobial Resistance in StaphylococcusRedox biology and oxidative stress