Directed Copper-Catalyzed Tandem Radical Cyclization Reaction of Alkyl Bromides and Unactivated Olefins
Ming Li, Yuke Li, Wan-Yuan Jia, Guo-Qing Sun, Fan Gao, Guo-Xiao Zhao, Yi‐Feng Qiu, Xi‐Cun Wang, Yong‐Min Liang, Zheng‐Jun Quan
Abstract
The free radical cyclization reaction is a promising strategy for ring framework formation. Herein, we report a copper-catalyzed tandem radical cyclization strategy for preparing substituted lactam derivatives. This reaction proceeds through a radical coupling approach, which not only allows a wide range of alkenes but also is quite compatible with the primary, secondary, and tertiary radicals. In addition, density functional theory calculations were performed to gain insights into the reaction mechanism.
Topics & Concepts
ChemistryTandemRadicalRadical cyclizationCatalysisAlkylCopperPrimary (astronomy)Cascade reactionCombinatorial chemistryRing (chemistry)Functional groupPhotochemistryMedicinal chemistryOrganic chemistryAstronomyComposite materialPolymerMaterials sciencePhysicsCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsCatalytic Cross-Coupling Reactions