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Blocking endothelial TRPV4-Nox2 interaction helps reduce ROS production and inflammation, and improves vascular function in obese mice

Mengru Gao, Jing Han, Yifei Zhu, Chunlei Tang, Liangliang Liu, Wang Xiao, Xin Ma

2021Journal of Molecular and Cellular Cardiology21 citationsDOI

Topics & Concepts

TRPV4Oxidative stressVasodilationInflammationNADPH oxidaseNicotinamide adenine dinucleotide phosphateEndothelial dysfunctionChemistryReactive oxygen speciesPharmacologyInternal medicineEndocrinologyTransient receptor potential channelBiochemistryMedicineReceptorOxidase testEnzymeIon Channels and ReceptorsThermoregulation and physiological responsesHeart Rate Variability and Autonomic Control
Blocking endothelial TRPV4-Nox2 interaction helps reduce ROS production and inflammation, and improves vascular function in obese mice | Litcius