Histamine-dependent interactions between mast cells, glia, and neurons are altered following early-life adversity in mice and humans
Jonathon L. McClain, Elvio Mazzotta, Nidia Maradiaga, Natalia Duque‐Wilckens, Iveta Grants, Alfred J. Robison, Fievos L. Christofi, Adam J. Moeser, Brian D. Gulbransen
2020American Journal of Physiology-Gastrointestinal and Liver Physiology34 citationsDOIOpen Access PDF
Abstract
Early-life adversity places an individual at risk for developing functional gastrointestinal disorders later in life through unknown mechanisms. Here, we show that interactions between mast cells and glia are disrupted by early-life stress in mice and that histamine is a potential mediator of mast cell-glial interactions.
Topics & Concepts
Glial fibrillary acidic proteinHistamineMast cellBiologyNeurogliaMyenteric plexusEnteric nervous systemCell biologyAstrocyteReceptorImmunohistochemistryPathologyCentral nervous systemNeuroscienceImmunologyEndocrinologyMedicineBiochemistryGastrointestinal motility and disordersInfant Health and DevelopmentChild Nutrition and Feeding Issues