Protein language models-assisted optimization of a uracil-N-glycosylase variant enables programmable T-to-G and T-to-C base editing
Yan He, Xibin Zhou, C.-H. Chang, Ge Chen, Weikuan Liu, Geng Li, Xiaoqi Fan, Mingsun Sun, Chensi Miao, Qianyue Huang, Yunqing Ma, Fajie Yuan, Xing Chang
Topics & Concepts
Cytidine deaminaseTransversionUracil-DNA glycosylaseBiologyDNA glycosylaseDeaminationCytidineAdenine phosphoribosyltransferaseUracilBiochemistryMutationAdenosine deaminaseComputational biologyEnzymeBase excision repairGeneticsNucleotideDNADNA repairGenePurineCRISPR and Genetic EngineeringRNA and protein synthesis mechanismsGenomics and Phylogenetic Studies