Synthesis and antimicrobial activity of phosphorylated betaines
A. M. Gayneev, R. R. Davletshin, Irina V. Galkina, N. V. Davletshina, A. N. Sedov, Milyausha Mirkhuzina, Evgeniy Kuchaev, Daut R. Islamov
Abstract
Target phosphorylated betaines (1–3) were obtained by the quaternization reaction between potassium salt of amino phosphonate and alkyl halides. The structures of the compounds were investigated by IR and NMR spectroscopy. The molecular structure of isopropyl [(N-octyl-N,N-diethylammonio)methyl]phosphonate (2) was determined by a single crystal X-ray analysis. Compound 2 demonstrates a high antibacterial activity against bacterial strain Staphylococcus epidermidis.
Topics & Concepts
ChemistryPhosphonateAlkylAntimicrobialIsopropylPotassiumSalt (chemistry)HalideStaphylococcus epidermidisStereochemistryAntibacterial activityNuclear magnetic resonance spectroscopyOrganic chemistryMedicinal chemistryBacteriaStaphylococcus aureusBiologyGeneticsOrganophosphorus compounds synthesisSynthesis and Reactivity of Sulfur-Containing CompoundsPhosphorus compounds and reactions