New ionizable lipids for non-viral mRNA delivery with secondary amine cyclic ether head groups

Abstract

by quantifying liver protein expression. Using this rational lipid design strategy, we identified many candidates that outperformed the benchmark lipid (MC3), supporting the further development of this ionizable lipid class. Notably, several structure activity relationships (SARs) that highlight how sensitive ionizable lipid activity is to relatively minor structural changes are reported.

Topics & Concepts