Dysfunction of pulmonary epithelial tight junction induced by silicon dioxide nanoparticles via the ROS/ERK pathway and protein degradation
Yingqi Liu, Haiyan Wei, Jing Tang, Jiaming Yuan, Mingmin Wu, Chenjuan Yao, Kazuo Hosoi, Shali Yu, Xinyuan Zhao, Yu Han, Gang Chen
Topics & Concepts
OccludinTight junctionCell biologyMAPK/ERK pathwayDownregulation and upregulationProtein kinase AProtein degradationBarrier functionReactive oxygen speciesMMP9ChemistryKinaseBiologyBiochemistryGeneHeme Oxygenase-1 and Carbon MonoxideChronic Obstructive Pulmonary Disease (COPD) ResearchAir Quality and Health Impacts