A pH/ROS dual-responsive hydrogel promotes diabetic wound healing by controlled release of O2 and EGCG to induce angiogenesis and immunomodulation
Yongcen Chen, Xuemin Ma, Yajuan Hu, Huiyue Wang, Peirong Zhou, Xiaoping Tian, Haofeng Wang, Yun He, Gang Tao, Rui Cai, Junliang Chen
Topics & Concepts
ChemistryWound healingControlled releaseSchiff baseAngiogenesisGranulation tissueCovalent bondChitosanIn vivoBiophysicsReactive oxygen speciesSelf-healing hydrogelsSulfationGenipinPharmacologyCombinatorial chemistryBiochemistryAntioxidantRegeneration (biology)Drug deliveryDithiothreitolExtracellular matrixTherapeutic angiogenesisWound Healing and TreatmentsHydrogels: synthesis, properties, applicationsNanoplatforms for cancer theranostics