Theranostic Imaging Surrogates for Targeted Alpha Therapy: Progress in Production, Purification, and Applications
Bryce J. B. Nelson, John S. Wilson, Jan Andersson, Frank Wuest
Abstract
This article highlights recent developments of SPECT and PET diagnostic imaging surrogates for targeted alpha particle therapy (TAT) radiopharmaceuticals. It outlines the rationale for using imaging surrogates to improve diagnostic-scan accuracy and facilitate research, and the properties an imaging-surrogate candidate should possess. It evaluates the strengths and limitations of each potential imaging surrogate. Thirteen surrogates for TAT are explored: 133La, 132La, 134Ce/134La, and 226Ac for 225Ac TAT; 203Pb for 212Pb TAT; 131Ba for 223Ra and 224Ra TAT; 123I, 124I, 131I and 209At for 211At TAT; 134Ce/134La for 227Th TAT; and 155Tb and 152Tb for 149Tb TAT.
Topics & Concepts
Pet imagingSpect imagingNuclear imagingMedical physicsNuclear medicineMolecular imagingMedicinePositron emission tomographyIn vivoBiologyBiotechnologyRadiopharmaceutical Chemistry and ApplicationsRadiation Therapy and DosimetryMedical Imaging Techniques and Applications