Designer DNA nanocages modulate anti-oxidative and anti-inflammatory responses in tumor associated macrophages
Payal Vaswani, Dhiraj Bhatia
Abstract
immunosuppression. DNA tetrahedron (TD), a widely explored DNA nanocage, has shown a lot of potential in therapeutics. However, the role of TD still remains quite unexplored in immunology. Here, we first establish the anti-oxidative and anti-inflammatory role of TD. We then proceed with using TD as a therapeutic agent in tumor associated macrophages by modulating the response of PD-L1. The findings of this work create a base for TD in biological applications such as cancer immunotherapy.
Topics & Concepts
NanocagesCell biologyTumor microenvironmentCancer researchDNAMacrophageTumor cellsCancer cellInflammationNicheCancerChemistryBiologyImmunologyBiochemistryGeneticsIn vitroCatalysisImmune cells in cancerRNA Interference and Gene DeliveryNanoplatforms for cancer theranostics