<scp>Visible‐Light‐Driven Four‐Component</scp> Radical Relay Aminocarbonylation of Unactivated Alkenes<sup>†</sup>
Bin Lu, Feng‐Shuo Bao, Zi‐Wei He, Wen‐Jing Xiao, Jia‐Rong Chen
Abstract
Comprehensive Summary Catalytic four‐component radical carbonylation of unactivated alkenes has recently been recognized as a robust protocol for rapid construction of various structurally diverse carbonyl compounds. Given the significance of fluorine‐containing groups, this reaction class has been extensively applied to assembly of a variety of perfluoroalkyl carboxylic acid derivatives by transition metal catalysis. Herein, we report a visible‐light‐driven radical relay 1,2‐perfluoroalkylation aminocarbonylation of unactivated alkenes using CO gas as carbonyl source and 4CzIPN as organic photocatalyst. A wide range of alkenes and amines were well tolerated, providing the valuable β‐perfluoroalkylated amides with generally good yields and high chemoselectivity.