Increasing Azithromycin Resistance in Neisseria gonorrhoeae Due to NG-MAST 12302 Clonal Spread in Canada, 2015 to 2018
Pam Sawatzky, Walter Demczuk, Brigitte Lefebvre, Vanessa Allen, Mathew Diggle, Linda Hoang, Paul Van Caeseele, David Haldane, Jessica Minion, Michael R. Mulvey, Irene Martin
Abstract
locus as the mechanism of AZIR in isolates of ST-12302 and isolates genetically similar (differing by ≤5 bp), designated the ST-12302 genogroup, accounting for 65.2% of study isolates which were originally identified in central Canada but spread to other regions by 2018. Genomic analysis indicated that AZIR in Canadian N. gonorrhoeae expanded rapidly due to clonal spread of the ST-12302 genogroup. The rapid expansion of this AZIR clonal group in all regions of Canada is of concern. CGSTI are currently under review to address the increase in AZIR in Canada.
Topics & Concepts
Neisseria gonorrhoeaeGonorrheaAzithromycinBiologyMicrobiologyNeisseriaceaeAntibiotic resistanceMultilocus sequence typingVirologyDrug resistanceMolecular epidemiologyAntimicrobialIsolation (microbiology)TypingGonococcal infectionChlamydia trachomatisNeisseriaGenotypeWhole genome sequencingAntibioticsPolymerase chain reactionSexually transmitted diseaseAntibacterial agentChlamydiaceaeDNA sequencingReproductive tract infections researchBacterial Infections and VaccinesNeonatal and Maternal Infections