A multicenter retrospective study of 223 patients with t(14;16) in multiple myeloma
Sarah Goldman‐Mazur, Artur Jurczyszyn, Jorge J. Castillo, Anna Waszczuk‐Gajda, Norbert Grząśko, Jakub Radocha, Max Bittrich, K. Martin Kortüm, Alessandro Gozzetti, Lidia Usnarska‐Zubkiewicz, Julio Dávila, David Jayabalan, Rubén Niesvizky, Julia Kelman, Daniel Coriu, Laura Rosiñol, Łukasz Szukalski, Verónica González‐Calle, María‐Victoria Mateos, Krzysztof Jamroziak, Iwona Hus, Irit Avivi, Yaël C. Cohen, Anna Suska, Aimee Chappell, Deepu Madduri, Saurabh Chhabra, Ariel Kleman, Parameswaran Hari, Michel Delforge, Paweł Robak, Massimo Gentile, Izabela Kozłowska, Stuart L. Goldberg, Jacek Czepiel, Rebecca Silbermann, Adam J. Olszewski, Peter Barth, Gábor Mikala, Chor Sang Chim, Monika Długosz‐Danecka, Sebastian Grosicki, David H. Vesole
Abstract
The t(14;16) translocation, found in 3%-5% of newly diagnosed (ND) multiple myeloma (MM), has been associated with adverse outcomes. However, the studies establishing the characteristics of t(14;16) included solely small cohorts. The goal of the current international, multicenter (n = 25 centers), retrospective study was to describe the characteristics and outcomes of t(14;16) patients in a large, real-world cohort (n = 223). A substantial fraction of patients had renal impairment (24%) and hemoglobin <10 g/dL (56%) on initial presentation. Combined therapy of both immunomodulatory drug and proteasome inhibitor (PI) in the first line was used in 35% of patients. Autologous stem cell transplantation was performed in 42% of patients. With a median follow up of 4.1 years (95% CI 3.7-18.7), the median progression-free survival (PFS) and overall survival (OS) from first line therapy were 2.1 years (95% CI 1.5-2.4) and 4.1 years (95% CI 3.3-5.5), respectively. Worse OS was predicted by age > 60 years (HR = 1.65, 95% CI [1.05-2.58]), as well as revised International Scoring System (R-ISS) 3 (vs R-ISS 2; HR = 2.59, 95% CI [1.59-4.24]). In conclusion, based on the largest reported cohort of t(14;16) patients, quarter of this subset of MM patients initially presents with renal failure, while older age and the R-ISS 3 predict poor survival.