Effect of liposome surface modification with water-soluble phospholipid polymer chain-conjugated lipids on interaction with human plasma proteins
Anna Adler, Yuuki Inoue, Kristina Nilsson Ekdahl, Teruhiko Baba, Kazuhíko Ishihara, Bo Nilsson, Yuji Teramura
Abstract
-macroglobulin is detected on non-modified, PEGylated, and PMPC-liposomes with a shorter polymer chain. In addition, a correlation is shown among the PMPC molecular weight, molar ratio, and C3 binding. The MPC10-lipid cannot inhibit C3 binding efficiently, whereas surface modifications with 10 mol% MPC20-lipid and 5 mol% and 10 mol% MPC50-lipid suppress both total protein and C3 binding. Hence, liposome modification with PMPC-lipids can be a possible strategy for avoiding complement activation.
Topics & Concepts
Conjugated systemLiposomePhospholipidSurface modificationPolymerMaterials scienceChain (unit)BiophysicsChemistryBiochemistryOrganic chemistryNanotechnologyMembraneBiologyPhysical chemistryAstronomyPhysicsNanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryLipid Membrane Structure and Behavior