Proteomics of broad deubiquitylase inhibition unmasks redundant enzyme function to reveal substrates and assess enzyme specificity
Valentina Rossio, João A. Paulo, Joel M. Chick, Bradley Brasher, Steven P. Gygi, Randall W. King
Topics & Concepts
UbiquitinDeubiquitinating enzymeComputational biologyEnzymeRecombinant DNABiologyXenopusFunction (biology)Protein stabilityRedundancy (engineering)BiochemistryCell biologyChemistryGeneComputer scienceOperating systemUbiquitin and proteasome pathwaysAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and Disease