Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage
Huanyi Fu, Rongdiao Liu, Zixuan Jia, Ran Li, Feifeng Zhu, Wenxuan Zhu, Yangqing Shao, Yiyang Jin, Yuhua Xue, Jun Huang, Kunxin Luo, Xiang Gao, Huasong Lu, Qiang Zhou
Topics & Concepts
P-TEFbRNA polymerase IIPARP1DNA damageBiologyPolymeraseProcessivityMolecular biologyCell biologyTranscription (linguistics)Elongation factorPoly ADP ribose polymeraseDNARNABiochemistryGene expressionGeneRibosomePromoterLinguisticsPhilosophyDNA Repair MechanismsPARP inhibition in cancer therapyRNA Research and Splicing