Homing in on genomic instability as a therapeutic target in cancer
Craig M. Bielski, Barry S. Taylor
Abstract
While genomic instability is a hallmark of cancer, its genetic vulnerabilities remain poorly understood. Identifying strategies that exploit genomic instability to selectively target cancer cells is a central challenge in cancer biology with major implications for anti-cancer drug development.
Topics & Concepts
Genome instabilityCancerCancer cellComputational biologyBiologyHoming (biology)Drug discoveryCancer researchBioinformaticsGeneticsDNADNA damageEcologyMicrotubule and mitosis dynamicsDNA Repair MechanismsEndoplasmic Reticulum Stress and Disease